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In a cohort of 309 patients from the Australian Ovarian Cancer Study (AOCS), we found three common single nucleotide polymorphisms (SNPs) in ABCB1 (C1236T (rs1128503), G2677T/A (rs2032582) and C3435T (rs1045642)) were associated with significant differences in progression free survival (PFS) for the subgroup of women with 1cm residual disease who received paclitaxel and carboplatin first line chemotherapy. In this subgroup of patients, PFS was significantly longer for individuals who carried the minor T/A alleles at the 2677G>T/A compared with homozygote GG carriers (HZ = 0.61, 95% CI 0.45 0.83; p = 0.002)8. A similar effect was demonstrated in 281 patients from Scottish Randomised Trial in Ovarian Cancer 1 (SCOTROC1) who had no residual disease after surgery and received carboplatin and paclitaxel or docetaxel combination chemotherapy8.
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Expression of activation markers and intracellular cytokines among monocytic subsetsMean Fluorescence Intensities (MFIs) of activation markers and intracellular cytokines of CM treated or CM+LGG treated « classical » CD14hiCD16 , « intermediate » CD14hiCD16lo and « non classical » CD14loCD16lo monocytic subsets are shown in Fig. 2. Within « classical » CD14hiCD16 monocytic subset, both CM and CM+LGG decreased CD11b MFI but CM+LGG increased TNF MFI.
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